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KMID : 0363420090230010023
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Journal of Korean Oriental Pediatrics
2009 Volume.23 No. 1 p.23 ~ p.35
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Effects of Kakamsodokum (KKSDU) on Atopic Dermatitis-like Skin Lesions in NC/Nga Mouse
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Song Hyun-Jee
Han Jae-Kyung
Kim Yun-Hee
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Abstract
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Objectives: The purpose of this study is to investigate the effect of Kakamsodokum (KKSDU) on atopic dermatitis in an in-vitro experiment using an NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the condition in humans.
Methods: We evaluated , IL-6, , , IL-10 mRNA, CD4+/, and CD4+CD25+foxp3+ in B and T cells of NC/Nga atopic dermatitis mouse by real-time PCR and intracellular staining in vitro.
Results: KKSDU medicines supressed , IL-6, , mRNA and increased IL-10 mRNA in B cells. CD4+/ and CD4+CD25+foxp3+ in T cells were increased by KKSDU.
Conclusions: KKSDU on atopic dermatitis might be very effective to the atopic dermatitis treatment.
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KEYWORD
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Atopic dermatitis, Kakamsodokum, NC/Nga mouse
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